![]() Newly formed cortical cells from the stem/progenitor cells move inward to the corticomedullary boundary during development. In mice, the adrenal capsule and the ZG contain stem and progenitor cells, respectively ( King et al. Although the origin and the lineage relationship between definitive zones and the fetal zone requires further investigation, lineage tracing experiments using mouse models have shown that definitive zones originate from the same group of cells ( Zubair et al. Within the first two to three weeks after birth, the fetal zone undergoes rapid regression through apoptosis ( Spencer et al. This transient cortical compartment grows rapidly from 8- to 30-week gestation leading to the fetal adrenal gland being 10- to 20-fold larger than the adult adrenal gland. In human fetal adrenals, there is another cortical layer in the inner cortex next to the medulla named the ‘fetal zone’ ( Ishimoto & Jaffe 2011). ![]() Zona glomerulosa (ZG), zona fasciculata (ZF) and zona reticularis (ZR) are the three major cortical zones (definitive zones) in the mammalian adrenal gland.
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